2-AG is something that plays a major part in the balance and the maintenance of the body. It also works in different functions including the sensation of pain, inflammation, the plasticity of synapses, the stress response of the body, emotion, and the balance of energy. 

This was first found in 1995, and it’s something that was the second endocannabinoid out there. Here, we’ll go over how this works, and the best ways to increase these too. 

How it Works in the system 

2-AG is one that’s the most abundant within the body and is considered an agonist of your CB1 and 2 receptors. This is something that’s found in a lot of the CNS, and the neurons in the brain are regulated through this. 

It works to help with the following: 

• Regulating the appetite
• Improving immunity 
• Managing pain 

Basically, the body relies on this to properly maintain homeostasis, or balance of the body. How this works is something that we’re still trying to understand, but we’ve managed to theorize that it’s a neuromodulator, which is a fancy word for sending messages to the neurons in order to release commands that affect the other neuron cells too. 

This is one that’s a messenger, and it works to bind and stimulate your receptors, causing them to be fully activated. For instance, when this binds to the CB1 receptor, it signals to the body to release different chemicals that also relieve inflammation and pain. 

The Benefits 

2-AG is one that is really important for ensuring that your body functions properly. 

Some of the conditions that it helps with do include: 

• MS as it controls spasms 
• Arthritis as it reduces inflammation and pain 
• Some cancers, since it is anti-tumor in effects 
• Parkinson’s, as it’s neuroprotective 
• Anxiety along with depression, since it can be antidepressant, and also have anxiolytic effects to this too. 
• Chronic pain, as this can strengthen or reduce the pain signals which are sent 

Are there Risks? 

Well, it can impact how effective this is at controlling the pain, so if you’re constantly doing this, it wears off in efficacy over time. 

Also, it can also cause psychosis if you’re activating those CB1 receptors, so keep that in mind. 

How you can increase this 

This is a chemical that does happen naturally within the body, but the thing is, you can increase this mainly by making sure that the MAGL enzymes are there and try to mitigate the enzymes that are there. 

Some people can use MAGL inhibitors, but they’re not as effective as the more natural means to increase 2-AG. 

The increase of this can be done through the following: 

• Sleeping better 
• Exercising 
• Consuming some cannabis 
• Having a diet that’s rich in anti-inflammatory foods such as avocados, blueberries, and cheeriest 

These are a few of the ways to naturally increase it, but a lot of people turn to cannabis as well as a supplement to work with this. 

The best thing to take from this is that it’s something that’s still a newer chemical. 

We don’t know a lot about what 2-AG can do to the body, and all of the effects of this on your endocannabinoid receptors. however, I’m pretty sure that, with the discoveries that we get of this, there will be more discoveries with time, that’ll help us reveal more and more about the endocannabinoid system, and also what it can do for you, including the benefits that are with this as well, and the effects that this may cause for you.